The Scream films follow Sidney Prescott and her war against a succession of murderers who adopt the guise of Ghostface to stalk and torment their victims. Sidney receives support from town deputy and later sheriff Dewey Riley, tabloid reporter and writer Gale Weathers, and film-geek Randy Meeks, along with various friends, romantic partners, and other acquaintances that change as the series progresses. From the fifth film onwards, the focus shifts to Samantha Carpenter, and her sister, Tara, who are targeted due to their connection to the original killers. Together with their friends and some of the original survivors (including Sidney, Gale, Dewey, and Kirby), they must contend with new Ghostface killers with motives that may sometimes be connected to the in-universe Stab movies.
A year after the murder of her mother, a teenage girl is terrorized by a masked killer who targets her and her friends by using scary movies as part of a deadly game.
Two years after the first series of murders, as Sidney acclimates to college life, someone donning the Ghostface costume begins a new string of killings.
While Sidney and her friends visit the Hollywood set of Stab 3, the third film based on the Woodsboro murders, another Ghostface killer rises to terrorize them.
25 years after a streak of brutal murders shocked the quiet town of Woodsboro, Calif., a new killer dons the Ghostface mask and begins targeting a group of teenagers to resurrect secrets from the town's deadly past.